6533b7ddfe1ef96bd127400f
RESEARCH PRODUCT
Exploring Evolution in Ceboidea (Platyrrhini, Primates) by Williams-Beuren Probe (HSA 7q11.23) Chromosome Mapping
F. BigoniOrsola PriviteraBarbara PiconeAntonella LanninoRoscoe StanyonFrancesca DumasLuca Sineosubject
Geneticsmedicine.diagnostic_testPhylogenetic treeChromosome MappingChromosomeKaryotypePlatyrrhiniSettore BIO/08 - AntropologiaBiologybiology.organism_classificationBiological EvolutionAtelinaeMOLECULAR CYTOGENETICS PRIMATES EVOLUTION WILLIAMS SYNDROME LOCUS NEOTROPICAL MONKEYS SYNTENY 7 FLUORESCENCE IN SITU HYBRIDISATION PHYLOGENYPhylogeneticsCebidaemedicineAnimalsAnimal Science and ZoologyEcology Evolution Behavior and SystematicsFluorescence in situ hybridizationSyntenydescription
The ancestral platyrrhine karyotype was characterised by a syntenic association of human 5 and a small segment of human 7 orthologues. This large syntenic association has undergone numerous rearrangements in various phylogenetic lines. We used a locus-specific molecular cytogenetic approach to study the chromosomal evolution of the human 7q11.23 orthologous sequences (William-Beuren syndrome, WS) in various Ceboidea (Platyrrhini) species. The fluorescent in situ hybridisation of the WS probe revealed a two-way pattern of chromosomal organisation that suggests various evolutionary scenarios. The first pattern (seen in Callimico and Saimiri ) includes a fairly simple disruption of the 7/5 syntenic association by a chromosome fission. The second pattern (seen in Atelinae, Alouattinae and in Callicebus ) is characterised by an increasing complexity in the 7/5 association as a consequence of a series of inversions and translocations resulting in different syntenic associations. These data support recent proposals for phylogenomic groupings of New World monkeys. The study also illustrates how single-locus probe hybridisations can reveal intrachromosomal rearrangements.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2007-11-19 | Folia Primatologica |