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RESEARCH PRODUCT
Sperm DNA fragmentation: An early and reliable marker of air pollution.
Maria Carmela RoccheriSalvatore RaimondoTiziana NotariLuigi MontanoAntonino GuglielminoLaura CarrilloDomenico CaroneRosanna ChiappettaChiara MartinoGiovanni RuvoloGiosuè Lo BoscoLiana Boscosubject
0301 basic medicineAdultMaleendocrine systemHealth Toxicology and MutagenesisAir pollutionDNA FragmentationBiologymedicine.disease_causeToxicologyAndrology03 medical and health sciences0302 clinical medicineAir PollutionmedicineHumansIn patientSettore BIO/06 - Anatomia Comparata E Citologiareproductive and urinary physiologySperm motilityTUNELPharmacologyAir Pollutants030219 obstetrics & reproductive medicineurogenital systemSperm dnaApoptosiGeneral MedicineEnvironmental exposureEnvironmental ExposureSpermSpermatozoaSCD030104 developmental biologyEnvironmental healthItalySteelSperm MotilityDNA fragmentationParticulate MatterReproductive capacitydescription
Environmental factors could have a key role in the continuous and remarkable decline of sperm quality observed in the last decades. This study compared the seminal parameters and sperm DFI in men living in areas with different levels of air pollution. Results demonstrate that both steel plants workers and patients living in a high polluted area show a mean percentage of sperm DNA fragmentation above 30%, highlighting a clear sperm damage. In this work, two different techniques were used to measure sperm DNA damage in patientsâ groups, finding in both cases a high sperm DFI in patients living in polluted areas. We candidate sperm DNA fragmentation as a valuable early marker of the presence and harmful effects of pollution. We suggest that sperm DNA evaluation could be both an indicator of individual health and reproductive capacity, and a suitable datum to connect the surrounding environment with its effects.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-10-20 | Environmental toxicology and pharmacology |