6533b7ddfe1ef96bd1274852
RESEARCH PRODUCT
Giant-cell tumor of bone, stage II, displaying translocation t(12;19)(q13;q13).
C. I. FernandezAntonio Llombart-boschConcha López-ginésCarmen CardaRosa Noguerasubject
AdultPathologymedicine.medical_specialtyChromosomal translocationBone NeoplasmsChromosomal rearrangementStage iiBiologyTranslocation GeneticPathology and Forensic Medicinelaw.inventionTissue culturelawmedicineHumansMolecular BiologyNeoplasm StagingNeovascularization PathologicGiant Cell TumorsKaryotypeCell BiologyGeneral Medicinemedicine.diseaseImmunohistochemistryKaryotypingImmunohistochemistryFemaleElectron microscopeGiant-cell tumor of bonedescription
A new case of giant-cell tumour (GCT) of bone with benign histological features, clinical stage II, has been reviewed with immunohistochemistry and electron microscopy. After short-term tissue culture the karyotype, using G-banding techniques, presented a consistent translocation t(12;19)(q13;q13). Nude mice xenografts of the tumour were unsuccessful after 6 months of follow-up. Presence of such chromosomal rearrangement may be related to locally aggressive, histologically benign giant-cell tumors of bone.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1989-01-01 | Virchows Archiv. A, Pathological anatomy and histopathology |