6533b7ddfe1ef96bd1274885
RESEARCH PRODUCT
Comparative study of eco- and cytotoxicity during biotransformation of anthraquinone dye Alizarin Blue Black B in optimized cultures of microscopic fungi
Konrad A. SzychowskiTeresa Korniłłowicz-kowalskaAgata ŚWięciłoKamila Rybczyńska-tkaczyksubject
0301 basic medicineCell SurvivalHealth Toxicology and MutagenesisAnthraquinones010501 environmental sciencesAlizarin01 natural sciencesLepidium sativumCell LineWater Purification03 medical and health scienceschemistry.chemical_compoundBiotransformationYeastsToxicity TestsHumansBiodecolorizationViability assayColoring AgentsCytotoxicityBiotransformationYeast model0105 earth and related environmental sciencesbiologyProoxidative toxicityPublic Health Environmental and Occupational HealthTrichoderma harzianumGeneral Medicinebiology.organism_classificationPollutionYeastHaematonectria haematococcaBiodegradation Environmental030104 developmental biologyBiochemistrychemistryPhytotoxicityDetoxificationOxidoreductasesOxidation-ReductionWater Pollutants Chemicaldescription
The aim of this study was to select optimal conditions (C and N sources, initial pH and temperature) for biodecolorization of 0.03% anthraquinone dye Alizarin Blue Black B (ABBB) by microscopic fungi: Haematonectria haematococca BwIII43, K37 and Trichoderma harzianum BsIII33. The phenolic compounds, phytotoxicity (Lepidium sativum L.), biotoxicity (Microtox), cytotoxicity and yeast viability assay were performed to determine the extent of ABBB detoxification. Biodecolorization and detoxification of 0.03% ABBB in H. haematococca BwIII43 and T. harzianum BsIII33 cultures was correlated with extracellular oxidoreductases activity. In turn, secondary products, toxic to human fibroblasts and respiring sod1 Saccharomyces cerevisiae cells, were formed in H. haematococca K37 strain cultures, despite efficient decolorization.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-07-02 | Ecotoxicology and Environmental Safety |