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RESEARCH PRODUCT

Milder forms of atherogenic dyslipidemia in ovulatory versus anovulatory polycystic ovary syndrome phenotype

Ilenia PepeGiovam Battista RiniEnrico CarminaGiatgen A. SpinasManfredi RizzoGaetana Di FedeKaspar BerneisMartin Hersberger

subject

AdultOvulationmedicine.medical_specialtySettore MED/09 - Medicina Internaendocrine system diseases10265 Clinic for Endocrinology and Diabetology610 Medicine & healthBiologyAnovulationchemistry.chemical_compoundInsulin resistancepolycystic ovary syndrome lipids lipoproteins cardiovascular riskRisk FactorsInternal medicinemedicineHumansTriglyceridesTestosteroneDyslipidemiasTriglycerideRehabilitationHyperandrogenismObstetrics and Gynecologynutritional and metabolic diseases2729 Obstetrics and GynecologyCholesterol LDL2743 Reproductive MedicineAtherosclerosismedicine.diseasePolycystic ovarySettore MED/40 - Ginecologia E Ostetriciafemale genital diseases and pregnancy complicationsCholesterolEndocrinologyReproductive Medicinechemistry10036 Medical ClinicFemalelipids (amino acids peptides and proteins)DyslipidemiaPolycystic Ovary SyndromeLipoprotein

description

BACKGROUND: Dyslipidemia is common in women with polycystic ovary syndrome (PCOS) but its prevalence in different PCOS phenotypes is still largely unknown. METHODS: We measured plasma lipids and lipoproteins in 35 anovulatory PCOS (age: 25 ± 6 years, BMI: 28 ± 6 kg/m2), 15 ovulatory PCOS (age: 30 ± 6 years, BMI: 25 ± 3 kg/m2) and 27 healthy women (controls) age- and BMI-matched with ovulatory PCOS. PCOS was diagnosed by the presence of clinical or biologic hyperandrogenism associated with chronic anovulation and/or polycystic ovaries at ultrasound. In women with normal menses chronic anovulation was indicated by low serum progesterone levels (<9.54 nmol/l) during midluteal phase (days 21-24) in two consecutive menstrual cycles. RESULTS: Total cholesterol, triglycerides and low-density lipoprotein (LDL)-cholesterol levels increased and high-density lipoprotein (HDL)-cholesterol decreased from controls to ovulatory and then to anovulatory PCOS (all P < 0.05). Levels of lipoprotein(a) (Lp(a)) and small, dense LDL increased (P < 0.0001 for both) and LDL size reduced (P < 0.005) between groups. Insulin resistance (by HOMA) showed a positive correlation with triglycerides and small, dense LDL and an inverse correlation with HDL-cholesterol and LDL size (P < 0.05 for all) in both PCOS phenotypes. No significant correlations were found with testosterone levels. At multivariate analysis, insulin resistance was independently associated with HDL-cholesterol and small, dense LDL in both PCOS phenotypes and with triglyceride concentrations in ovulatory PCOS only. CONCLUSIONS: Women with ovulatory PCOS showed milder forms of atherogenic dyslipidemia than anovulatory PCOS and this seemed to be related to the extent of insulin resistance. Future prospective studies are needed to assess the relative contribution of such alterations on cardiovascular risk

yearjournalcountryeditionlanguage
2017-08-02
https://dx.doi.org/10.5167/uzh-26430