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RESEARCH PRODUCT

Serum Malondialdehyde Correlates with Therapeutic Efficiency of High Activity Antiretroviral Therapies (HAART) in HIV-1 Infected Children

Nuria MarínFrancisco Bosch-morellJoaquín RomáEnrique J. JareñoMaría MuriachSiv JohnsenFrancisco J. RomeroLena MarselouBelén Romero

subject

Anti-HIV Agentsbusiness.industryHuman immunodeficiency virus (HIV)virus diseasesHIV InfectionsGeneral Medicinemedicine.disease_causeMalondialdehydeBiochemistryAntiretroviral therapyOxidative Stresschemistry.chemical_compoundchemistryAntiretroviral Therapy Highly ActiveMalondialdehydeImmunologyHIV-1medicineHumansHigh activityDrug Therapy CombinationChildbusinessBiomarkersOxidative stress

description

Serum malondialdehyde (MDA) levels are increased in human immunodeficiency virus (HIV)-infected children, as it happens also in infected adult individuals. Introduction of high activity antiretroviral therapy (HAART) has promoted an intense decline in morbidity and mortality of these patients. Here we present data on the effect of HAART on serum MDA of HIV+ children and compare them with levels prior to HAART. MDA levels reflect, as other markers do, the HAART-induced clinical improvement and probably also the pro-oxidant/antioxidant side effects of the different drugs used. The results herein allow the proposal of including serum MDA levels as an additional parameter for the clinical management of HIV+ children.

yearjournalcountryeditionlanguage
2002-06-20Free Radical Research
https://doi.org/10.1080/10715760290019363