0000000000413939

AUTHOR

Enrique J. Jareño

showing 4 related works from this author

Serum Malondialdehyde Correlates with Therapeutic Efficiency of High Activity Antiretroviral Therapies (HAART) in HIV-1 Infected Children

2002

Serum malondialdehyde (MDA) levels are increased in human immunodeficiency virus (HIV)-infected children, as it happens also in infected adult individuals. Introduction of high activity antiretroviral therapy (HAART) has promoted an intense decline in morbidity and mortality of these patients. Here we present data on the effect of HAART on serum MDA of HIV+ children and compare them with levels prior to HAART. MDA levels reflect, as other markers do, the HAART-induced clinical improvement and probably also the pro-oxidant/antioxidant side effects of the different drugs used. The results herein allow the proposal of including serum MDA levels as an additional parameter for the clinical manag…

Anti-HIV Agentsbusiness.industryHuman immunodeficiency virus (HIV)virus diseasesHIV InfectionsGeneral Medicinemedicine.disease_causeMalondialdehydeBiochemistryAntiretroviral therapyOxidative Stresschemistry.chemical_compoundchemistryAntiretroviral Therapy Highly ActiveMalondialdehydeImmunologyHIV-1medicineHumansHigh activityDrug Therapy CombinationChildbusinessBiomarkersOxidative stressFree Radical Research
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Serum malondialdehyde in HIV-seropositive children negatively correlates with CD4+ lymphocytes count.

1998

Human immunodeficiency virus (HIV) infection is associated with oxidative stress as it has been demonstrated in adult-seropositive individuals. We show in this study that serum malondialdehyde (MDA) concentration of HIV-infected children was significantly higher than in control children. A negative correlation (r = -0.515) was found in HIV-infected children between their CD4+ lymphocyte count, and MDA concentration but not with serum antioxidant status. The increase of MDA concentration in HIV-seropositive children confirms the involvement of oxidative stress in the pathophysiology of this infection also in childhood. Because of the importance of oxidative stress and antioxidants for HIV vi…

MaleAntioxidantHiv seropositivemedicine.medical_treatmentLymphocyteClinical BiochemistryBiologymedicine.disease_causeBiochemistrychemistry.chemical_compoundReference ValuesHIV SeronegativityMalondialdehydeHIV SeropositivitymedicineAdjuvant therapyHumansChildGeneral MedicineMalondialdehydePathophysiologyCD4 Lymphocyte CountOxidative Stressmedicine.anatomical_structurechemistryViral replicationChild PreschoolImmunologyMolecular MedicineRegression AnalysisFemaleOxidative stressBiomarkersBioFactors (Oxford, England)
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Serum Malondialdehyde in HIV Seropositive Children

1998

Human immunodeficiency virus (HIV) infection is associated with oxidative stress as it has been demonstrated in adult seropositive individuals. We show in this study that serum malondialdehyde (MDA) concentration of HIV infected children was significantly higher than in control children. Moreover, a statistically significant decreased serum antioxidant status was detected in HIV infected children when compared with controls. No correlation was found in HIV infected children between their clinical or immunological categories, CD4+ lymphocyte count or CD4+/CD8+ ratio, and MDA concentration or serum antioxidant status. Newborn from HIV seropositive mothers had also a higher MDA concentration i…

MaleAdolescentLymphocyteBirth weightCD4-CD8 RatioCD4-CD8 Ratiomedicine.disease_causeBiochemistryAntioxidantschemistry.chemical_compoundMalondialdehydePhysiology (medical)HIV SeropositivitymedicineHumansChildbusiness.industryInfant NewbornInfantGestational ageMalondialdehydePathophysiologyCD4 Lymphocyte CountOxidative Stressmedicine.anatomical_structurechemistryChild PreschoolCord bloodImmunologyFemalebusinessOxidative stressFree Radical Biology and Medicine
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Lipid peroxidation products and antioxidants in human disease.

1998

Lipid peroxidation (LPO) is a free radical-related process that in biologic systems may occur under enzymatic control, e.g., for the generation of lipid-derived inflammatory mediators, or nonenzymatically. This latter form is associated mostly with cellular damage as a result of oxidative stress, which also involves cellular antioxidants in this process. This article focuses on the relevance of two LPO products, malondialdehyde (MDA) and 4-hydroxynonenal (HNE), to the pathophysiology of human disease. The former has been studied in human serum samples of hepatitis C virus-infected adults and human immunodeficiency virus-infected children. In these two cases it is shown that the specific ass…

AdultHealth Toxicology and MutagenesisHIV InfectionsPharmacologyBiologymedicine.disease_causeAntioxidantsLipid peroxidationMicechemistry.chemical_compoundMalondialdehydemedicineAnimalsHumansDiseaseChildchemistry.chemical_classificationAldehydesGlutathione PeroxidaseGlutathione peroxidasePublic Health Environmental and Occupational HealthGlutathioneMalondialdehydeHepatitis CIn vitroPathophysiologyRatsOxidative StressEnzymechemistryImmunologyBlood VesselsLipid PeroxidationOxidative stressResearch ArticleEnvironmental Health Perspectives
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