6533b7ddfe1ef96bd127493b

RESEARCH PRODUCT

Immunological characteristics of non-intensive care hospitalized COVID-19 patients: A preliminary report

Corrao SalvatoreFrancesco GervasiFrancesca Di BernardoNicola CatalanoMassimo RaspantiNatoli GiuseppeChristiano Argano

subject

Lymphocytelcsh:MedicineArticleimmune system deficiency03 medical and health sciences0302 clinical medicineImmune systemImmunityIntensive caremedicineCytotoxic T cell030304 developmental biology0303 health sciencesbiologybusiness.industrySARS-CoV-2lcsh:RGeneral MedicineAcquired immune systemmedicine.anatomical_structureGranzymemultiparametric flow cytometryImmunologybiology.proteinbusinessCluster analysis Immune system deficiencyMultiparametric flow cytometry SARS-CoV-2CD8030215 immunologycluster analysis

description

The outbreak of coronavirus disease 2019 (COVID-19) is posing a threat to global health. This disease has different clinical manifestations and different outcomes. The immune response to the novel 2019 coronavirus is complex and involves both innate and adaptive immunity. In this context, cell-mediated immunity plays a vital role in effective immunity against SARS-CoV-2. Significant differences have been observed when comparing severe and non-severe patients. Since these immunological characteristics have not been fully elucidated, we aimed to use cluster analysis to investigate the immune cell patterns in patients with COVID-19 who required hospitalization but not intensive care. We identified four clusters of different immunological patterns, the worst being characterized by total lymphocytes, T helper lymphocytes CD4+ (CD4+), T cytotoxic lymphocytes CD8+ (CD8+) and natural killer (NK) cells below the normal range, together with natural killer lymphocyte granzyme &lt

yearjournalcountryeditionlanguage
2021-02-01
10.3390/jcm10040849https://hdl.handle.net/10447/583339