6533b7ddfe1ef96bd127499a
RESEARCH PRODUCT
Synthesis and biological evaluation of pyridinebetaine A and B
Miguel A. GonzálezLiliana Betancur-galvisJulieth Correa-royeroAna M Mesasubject
AntifungalAntifungal Agentsmedicine.drug_classHerpesvirus 1 HumanPlant ScienceBiologyVirus Replicationmedicine.disease_causeAntiviral AgentsBiochemistryAnalytical ChemistryMicrobiologyStructure-Activity RelationshipAlkaloidsChlorocebus aethiopsmedicineAnimalsHumansCytotoxic T cellVero CellsBiological evaluationMolecular StructureOrganic ChemistryFungiVirologyBetaineHerpes simplex virusViral replicationHeLa Cellsdescription
The synthesis of the marine natural products pyridinebetaine A and B is reported. The biological evaluation of pyridinebetaine A and B and several analogues as cytotoxic, antifungal and antiviral agents is also described. Unfortunately, none of the compounds tested showed relevant antifungal or cytotoxic activity. Only pyridinebetaine B reduced the Herpes simplex virus type 1 virus replication, though only weakly.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-10-22 | Natural Product Research |