0000000000414210

AUTHOR

Julieth Correa-royero

0000-0001-9211-298x

showing 3 related works from this author

Synthesis and biological evaluation of pyridinebetaine A and B

2009

The synthesis of the marine natural products pyridinebetaine A and B is reported. The biological evaluation of pyridinebetaine A and B and several analogues as cytotoxic, antifungal and antiviral agents is also described. Unfortunately, none of the compounds tested showed relevant antifungal or cytotoxic activity. Only pyridinebetaine B reduced the Herpes simplex virus type 1 virus replication, though only weakly.

AntifungalAntifungal Agentsmedicine.drug_classHerpesvirus 1 HumanPlant ScienceBiologyVirus Replicationmedicine.disease_causeAntiviral AgentsBiochemistryAnalytical ChemistryMicrobiologyStructure-Activity RelationshipAlkaloidsChlorocebus aethiopsmedicineAnimalsHumansCytotoxic T cellVero CellsBiological evaluationMolecular StructureOrganic ChemistryFungiVirologyBetaineHerpes simplex virusViral replicationHeLa CellsNatural Product Research
researchProduct

Synthesis and biological evaluation of abietic acid derivatives

2009

A series of C18-oxygenated derivatives of abietic acid were synthesized and evaluated for their cytotoxic, antimycotic, and antiviral activities. In general, the introduction of an aldehyde group at C18 did improve the resultant bioactivity, while the presence of an acid or alcohol led to less active compounds.

Antifungal AgentsCarboxylic acidMolecular ConformationAntineoplastic AgentsAlcoholHerpesvirus 1 HumanMicrobial Sensitivity TestsPrimary alcoholAntiviral AgentsChemical synthesisAldehydeStructure-Activity Relationshipchemistry.chemical_compoundChlorocebus aethiopsDrug DiscoveryAnimalsHumansStructure–activity relationshipOrganic chemistryAbietic acidVero CellsCandidaCell ProliferationPharmacologychemistry.chemical_classificationDose-Response Relationship DrugAspergillus fumigatusOrganic Chemistryfood and beveragesStereoisomerismGeneral Medicineequipment and suppliesAspergilluschemistryDrug DesignAbietaneslipids (amino acids peptides and proteins)DiterpeneHeLa CellsEuropean Journal of Medicinal Chemistry
researchProduct

Synthesis and biological evaluation of dehydroabietic acid derivatives.

2010

A series of C18-oxygenated derivatives of dehydroabietic acid were synthesized from commercial abietic acid and evaluated for their cytotoxic, antimycotic, and antiviral activities.

KetoneAntifungal AgentsCarboxylic acidAntineoplastic AgentsHerpesvirus 1 HumanMicrobial Sensitivity TestsAldehydeChemical synthesisAntiviral Agentschemistry.chemical_compoundInhibitory Concentration 50Cell Line TumorDrug DiscoveryOrganic chemistryAnimalsHumansAbietic acidCytotoxicityPharmacologychemistry.chemical_classificationOrganic ChemistryFungifood and beveragesGeneral Medicineequipment and suppliesTerpenoidchemistryAbietaneslipids (amino acids peptides and proteins)DiterpeneHydrophobic and Hydrophilic InteractionsEuropean journal of medicinal chemistry
researchProduct