6533b7ddfe1ef96bd1274a90
RESEARCH PRODUCT
The role of freshwater copepods in the environmental risk assessment of caffeine and propranolol mixtures in the surface water bodies of Spain
Leonor Nozal MartínezWalter Dario Di MarzioTiziana Di LorenzoAndrea Castaño-sánchezPatricia Garcia-doncelDiana M. P. GalassiSanda Iepuresubject
Health Toxicology and Mutagenesis0208 environmental biotechnologyFresh Water02 engineering and technology010501 environmental sciences01 natural sciencesCiencias de la Tierra y relacionadas con el Medio Ambientechemistry.chemical_compoundCONCENTRATION ADDITIONPHARMACEUTICAL AND PERSONAL CARE PRODUCTSOceanografía Hidrología Recursos HídricosConcentration additionChemistry (all)General MedicinePropranololPollutionCrustaceansERAHealthEnvironmental chemistrySpecies sensitivity distributionSPECIES SENSITIVITY DISTRIBUTIONCaffeineCIENCIAS NATURALES Y EXACTASmedicine.drugEnvironmental EngineeringPropranololRisk AssessmentCopepodaCaffeinemedicineTD Environmental technology. Sanitary engineeringAnimalsEnvironmental ChemistryCRUSTACEANSToxicology and MutagenesisConcentration addition; Crustaceans; ERA; Pharmaceutical and personal care products; Species sensitivity distribution; Environmental Engineering; Environmental Chemistry; Chemistry (all); Pollution; Health Toxicology and MutagenesisPharmaceutical and personal care products0105 earth and related environmental sciencesEnvironmental risk assessmentPublic Health Environmental and Occupational HealthGeneral ChemistryQL Zoology020801 environmental engineeringchemistrySpainEnvironmental scienceSurface waterWater Pollutants Chemicaldescription
In this study we aimed at assessing: (i) the environmental risk posed by mixtures of caffeine and propranolol to the freshwater ecosystems of Spain; (ii) the sensitivity of freshwater copepod species to the two compounds; (iii) if the toxicity of caffeine and propranolol to freshwater copepods contributes to the environmental risk posed by the two compounds in the freshwater bodies of Spain. The environmental risk was computed as the ratio of MECs (i.e. the measured environmental concentrations) to PNECs (i.e. the respective predicted no-effect concentrations). The effects of caffeine and propranolol on the freshwater cyclopoid Diacyclops crassicaudis crassicaudis were tested both individually and in binary mixtures. Propranolol posed an environmental risk in some but not in all the surface water ecosystems of Spain investigated in this study, while caffeine posed an environmental risk to all the investigated freshwater bodies, both as single compound and in the mixture with propranolol. Propranolol was the most toxic compound to D. crassicaudis crassicaudis, while caffeine was non-toxic to this species. The CA model predicted the toxicity of the propranolol and caffeine mixture for this species. D. crassicaudis crassicaudis was much less sensitive than several other aquatic species to both compounds. The sensitivity of D. crassicaudis crassicaudis does not increase the environmental risk posed by the two compounds in the freshwater bodies of Spain, however, further testing is recommended since the effect of toxicants on freshwater copepods can be more pronounced under multiple stressors and temperature increasing due to climate change. Fil: Di Lorenzo, Tiziana. Consiglio Nazionale delle Ricerche; Italia. Istituto di Ricerca sugli Ecosistemi Terrestri; Italia Fil: Castaño Sánchez, Andrea. Universidad de Alcalá; España Fil: Di Marzio, Walter Dario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Luján. Departamento de Ciencias Básicas; Argentina Fil: García Doncel, Patricia. Universidad de Alcalá; España Fil: Nozal Martínez, Leonor. Universidad de Alcalá; España Fil: Galassi, Diana Maria Paola. Universita degli Studi dell'Aquila; Italia Fil: Iepure, Sanda. Universidad de Alcalá; España
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-04-01 |