6533b7ddfe1ef96bd1274aa4

RESEARCH PRODUCT

Desmopresssin and hemodilution: implications in doping.

subject

description

Blood doping improves physical performance in sport. This is the reason why the antidop- ing authorities subject athletes to blood tests. Plasma volume expanders are prohibited agents used to reduce an artifi cial increase in hemato- logical values using diff erent illegal practices. The aim of our study was to test whether desmo- pressin (DDAVP)-induced hemodilution would alter the concentration of hematological param- eters used to detect blood doping in sports. This was an intra-subject crossover study. Venous blood samples were obtained from eight physi- cally active males on two occasions. On the fi rst o ccasion the subjects ingested 1.5 L of mineral water and 4.3 μ g / kg of DDAVP. On the second occasion the subjects ingested 1.5 L of mineral water. The samples were analyzed for hemato- crit, hemoglobin, reticulocytes, OFF Hr-Score, glucose, albumin, creatinine and total proteins. After treatment with DDAVP we found a signifi - cant decrease in the hematocrit, hemoglobin and in the OFF Hr-Score values. We also found a sig- nifi cant decrease in glucose, albumin, creatinine and total proteins concentration; however, in this case, all the values were signifi cantly below the physiological levels. Treatment with DDAVP has a very eff ective hemodilution eff ect. We con- sider that this substance should be included in the WADA ' s prohibited list.