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RESEARCH PRODUCT

The Maternal Cytokine and Chemokine Profile of Naturally Conceived Gestations Is Mainly Preserved duringIn VitroFertilization and Egg Donation Pregnancies

David Hervas-marínVicente SerraJosé BellverAntonio PellicerB. PellicerAlicia Martínez-romeroAlicia Martínez-vareaAlfredo Perales-marín

subject

AdultProteomicslcsh:Immunologic diseases. Allergymedicine.medical_specialtyChemokineArticle SubjectT-Lymphocytesmedicine.medical_treatmentImmunologyFertilization in VitroPreeclampsiaPregnancyInternal medicinemedicineCluster AnalysisHumansImmunology and AllergyLongitudinal StudiesProspective StudiesInterleukin 8Pregnancy TrimestersPregnancyIn vitro fertilisationbiologybusiness.industryImmunityPregnancy OutcomeGeneral Medicinemedicine.diseaseInterleukin 10Endocrinologybiology.proteinCytokinesGestationFemalePregnancy TrimestersChemokineslcsh:RC581-607businessBiomarkersResearch Article

description

This prospective longitudinal study aimed at comparing maternal immune response among naturally conceived (NC;n=25),in vitrofertilization (IVF;n=25), and egg donation (ED;n=25) pregnancies. The main outcome measures were, firstly, to follow up plasma levels of interleukin (IL) 1beta, IL2, IL4, IL5, IL6, IL8, IL10, IL17, interferon gamma, tumor necrosis factor-alpha (TNFα), transforming growth factor-beta (TGFβ), regulated upon activation normal T-cell expressed and secreted (RANTES), stromal cell-derived factor 1 alpha (SDF1α), and decidual granulocyte-macrophage colony-stimulating factor (GM-CSF) during the three trimesters of pregnancy during the three trimesters of pregnancy; secondly, to evaluate if the cytokine and chemokine pattern of ED pregnant women differs from that of those with autologous oocytes and, thirdly, to assess if women with preeclampsia show different cytokine and chemokine profile throughout pregnancy versus women with uneventful pregnancies. Pregnant women in the three study groups displayed similar cytokine and chemokine pattern throughout pregnancy. The levels of all quantified cytokines and chemokines, except RANTES, TNFα, IL8, TGFβ, and SDF1α, rose in the second trimester compared with the first, and these higher values remained in the third trimester. ED pregnancies showed lower SDF1αlevels in the third trimester compared with NC and IVF pregnancies. Patients who developed preeclampsia displayed higher SDF1αplasma levels in the third trimester.

https://doi.org/10.1155/2015/128616