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RESEARCH PRODUCT

Molecularly Imprinted Polymers as Useful Sorbents for Bioanalysis

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description

The determination of various active compounds in different types of biological samples attracts recently considerable attention. Unfortunately, the complexity of such sample matrices requires the application of multistage analytical procedures, which by many analysts is considered the most critical step in the whole analytical process. Sample preparation techniques dedicated to bioanalysis must ensure effective isolation and enrichment of various, often trace, amounts of analytes. Furthermore, the high selectivity of extraction of the target analytes, in relation to other interfering substances co-presented in the sample, is important in this case. Therefore, over the last two decades, the potential of different types of sorbents, with various recognition properties, for sample pretreatment step for the bioanalytical application has been described in many scientific publications. One of the main trends is using a new type of specific sorption materials based on molecularly imprinted polymers (MIPs). In this review, the latest developments in MIPs preparation and application in the analysis of biological samples is discussed. Different imprinted sorption materials have been utilized in various extraction configurations, including solid-phase extraction, solid-phase microextraction, microextraction by packed sorbent, stir bar sorptive extraction, dispersive solid-phase extraction, and in a combination of hollow-fiber-supported liquid membrane with molecularly imprinted solid-phase extraction. The advantages and drawbacks of the application of MIPs used in bioanalytical approaches are summarized.