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RESEARCH PRODUCT
Infant and childhood growth and frailty in old age : the Helsinki Birth Cohort Study
Minna K. SalonenClive OsmondEero KajantieEero KajantieEero KajantieMika SimonenTaina RantanenM. B. Von BonsdorffMarkus J. HaapanenMia-maria PeräläPertti PohjolainenJohan G. ErikssonJohan G. Erikssonsubject
MaleAgingChildhood growthDiseasefrailtyBody sizeWeight GainpituuskasvukasvuelämänkaariArticlepainonnousuBody Mass IndexCohort Studiesvarhaislapsuus03 medical and health sciencesChild DevelopmentSex Factors0302 clinical medicinevanhuusRisk FactorsHumansMedicine030212 general & internal medicineRisk factorChildAgedlife coursegerasteniaFrailtybusiness.industryInfant NewbornInfantMean ageriskitekijätlapsuusrisk factorPhysical performanceChild PreschoolLife course approachFemaleGeriatrics and GerontologybusinessBirth cohort030217 neurology & neurosurgeryDemographydescription
BackgroundEvidence from life course studies highlights the importance of infant and childhood growth as risk factors for adulthood chronic diseases.MethodsIn this sub-study of the Helsinki Birth Cohort Study, we studied 1078 individuals who had both information on body size from birth to 12 years of age and who were assessed for frailty according to the Fried criteria at the mean age of 71 years.ResultsGreater BMI gain between 2 and 11 years in boys was associated with frailty in old age (age-adjusted RRR 2.36, 95% CI 1.21, 4.63). No similar associations were observed in girls.ConclusionsMen who were frail in old age experienced accelerated BMI gain in childhood compared with those men who were not frail. This was not observed in women, which suggests that the patterns of early growth predisposing to frailty may vary by sex.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-07-24 |