6533b7ddfe1ef96bd1275471

RESEARCH PRODUCT

Studies on puupehenone-metabolites of a Dysidea sp.: structure and biological activity

Rob W. M. Van SoestMargherita GavagninM. Letizia CiavattaVanessa RomeroEmiliano ManzoGuido CiminoYue-wei GuoM. Pilar Lopez GresaDominique Melck

subject

AntifungalMitochondrial respiratory chainbiologyMarine metabolitesmedicine.drug_classStereochemistryChemistryPuupehenoneOrganic ChemistryBiological activitySponges; Marine metabolites; Sesquiterpene-quinones; Antifungal; Antibacterial; Mitochondrial respiratory chain.biology.organism_classificationAntifungalBiochemistryAdductAntibacterialSpongeMitochondrial respiratory chainSpongesDrug DiscoverymedicineSesquiterpene-quinonesBIOQUIMICA Y BIOLOGIA MOLECULAR

description

[EN] Puupchenone (1) and a series of its congeners (2-6) have been isolated from a Dysidea sponge. The unprecedented 20-acetoxyhater-unnadienone (2) exhibiting a five-membered contracted ring, has been characterized. In addition, stereochemical assignment of two previously reported acetone adducts of puupehenone (5 and 6) has been made. Finally, the inhibition of mitochondrial respiratory chain as well as antibacterial and antifungal activities of all compounds has been evaluated. (c) 2006 Elsevier Ltd. All rights reserved.

yearjournalcountryeditionlanguage
2007-02-01Tetrahedron
10.1016/j.tet.2006.11.088https://doi.org/10.1016/j.tet.2006.11.088