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RESEARCH PRODUCT
TGF-beta as a T cell regulator in colitis and colon cancer
Markus F. NeurathMassimo FantiniChristoph Beckersubject
Endocrinology Diabetes and MetabolismT cellImmunologyBiologyGeneral Biochemistry Genetics and Molecular BiologyTCIRG1Interleukin 21T-Lymphocyte SubsetsTransforming Growth Factor betamedicineAnimalsHumansImmunology and AllergyCytotoxic T cellIL-2 receptorIntestinal MucosaAntigen-presenting cellZAP70Cell DifferentiationColitisNatural killer T cellDisease Models Animalmedicine.anatomical_structureColonic NeoplasmsImmunologyInflammation Mediatorsdescription
TGF-beta is a pleiotropic cytokine with powerful immunosuppressive functions. Mice deficient for TGF-beta1 show a dramatic phenotype with severe multiorgan inflammation and die shortly after birth. Recent investigations have highlighted the role of TGF-beta in suppression of T cell mediated autoimmune inflammation and anti-tumor immunity. In addition to its direct anti-inflammatory effects on T cells, TGF-beta has been implicated as central regulator of regulatory T cells. TGF-beta not only mediates the suppression of effector T cells by Tregs, recent evidence also reveals a role for TGF-beta along with TCR stimulation in the peripheral induction of regulatory T cells from naïve CD4+CD25- cells.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2005-08-02 | Cytokine & Growth Factor Reviews |