6533b7defe1ef96bd1275ae3

RESEARCH PRODUCT

CD4+CD25+ Regulatory T Cells and TGF-Beta in Mucosal Inflammation

Markus F. NeurathM.c. Fantini

subject

Adoptive cell transfermedicine.medical_treatmentT cellInflammationBiologymedicine.disease_causeCell biologyAutoimmunityImmune systemCytokinemedicine.anatomical_structureTGF beta signaling pathwaymedicineIL-2 receptormedicine.symptom

description

Transforming growth factor-beta (TGF-beta) is an anti-inflammatory cytokine which plays a key role in the maintenance of the immune system homeostasis. Indeed the abrogation of the TGF-beta signaling in immune cells leads to autoimmunity and inflammation in several organs including the gut. TGF-beta acts at multiple levels to maintain the immune system in check. However, TGF-beta has been recently shown to play a key role in the peripheral generation and function of CD4+CD25+ regulatory T cells, a subset of suppressive lymphocytes involved in the control of effector T cell activation and proliferation. Consistently abrogation of Tregs maturation as observed in different systems leads to a phenotype resembling that caused by the impairment of the TGF-beta signaling thus linking Tregs and TGF-beta activities. Here we review data generated in the last years at support of this link.

yearjournalcountryeditionlanguage
2008-01-01
https://doi.org/10.1007/978-0-387-77909-6_14