6533b7defe1ef96bd1275c03
RESEARCH PRODUCT
Conceptos nuevos sobre el sistema renina angiotensina
L. Estañ YagoF.j. Morales Olivassubject
medicine.medical_specialtyAliskirenBiologyPharmacologyAngiotensin IVchemistry.chemical_compoundEndocrinologychemistryInternal medicineRenin–angiotensin systemInternal MedicinemedicineCardiology and Cardiovascular MedicineReceptordescription
In recent years, new components of the renin-angiotensin system have been described. Five new polypeptides with their synthesis routes and the enzymes involved in their synthesis have been identified. Receptors for angiotensin 1–7, angiotensin IV and renin have also been described. The knowledge of local renin-angiotensin systems has been extended with the discovery of the intracellular systems. Mutations and polymorphisms in the genes of the different components of the renin-angiotensin system have been described. These could be involved in the development of hypertension and cardiovascular disease. In addition, aliskiren, the first component of the new group of renin direct inhibitors, has been introduced in the therapeutics. The first positive results of a clinical
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-09-01 | Hipertensión y Riesgo Vascular |