6533b7defe1ef96bd1275d88

RESEARCH PRODUCT

Sodium thiosulfate not always resolves calciphylaxis: an ambiguous response

Antonio PintoGiuseppe LicataGlauco MilioAntonino TuttolomondoSalvatore MiceliDomenico Di RaimondoSergio La PlacaMaurizio Li Vecchi

subject

medicine.medical_specialtyNecrosisSettore MED/09 - Medicina InternaIschemiaThiosulfatesSodium thiosulfateCritical Care and Intensive Care MedicineGastroenterologySubcutaneous fatSeverity of Illness IndexAntioxidantschemistry.chemical_compoundFatal OutcomeInternal medicineSeverity of illnessmedicineHumansChelating AgentsThiosulfateCalciphylaxisbusiness.industryCalciphylaxisGeneral MedicineMiddle Agedmedicine.diseasethiosulfate calciphylaxisSurgeryTreatment OutcomechemistryNephrologyFemalemedicine.symptombusinessBlood parameters

description

Calciphylaxis is a severe “vascular ossification–calcification,” associated with a very high mortality rate that involvesarterial wall, venular wall, and nerves resulting in ischemia and necrosis of skin, subcutaneous fat, visceral organs,and skeletal muscles. Sodium thiosulfate has recently been used as a novel treatment option for calciphylaxisbecause of its dual role as an antioxidant and a chelator. Multiple case reports demonstrated that such therapy hasresulted in pain relief and healing of skin ulceration. We report a case of calciphylaxis of large severity that had anambiguous response to sodium thiosulfate treatment (improvement of symptomatology and skin lesions, improve-ment of blood parameters, worsening of general conditions, and consciousness until death)

yearjournalcountryeditionlanguage
2011-01-10
10.3109/0886022x.2010.536288http://hdl.handle.net/10447/57499