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RESEARCH PRODUCT
Inflammation and frailty in the elderly: A systematic review and meta-analysis
Roberto PelusoNicola VeroneseAhmet Turan IsikGiuseppe SergiMarco SolmiMarcello MaggioClaudio LuchiniYu-tzu WuEnzo ManzatoBrendon StubbsStefania MaggiPaola LucatoPinar SoysalA. Matthew PrinaTheodore D. Coscosubject
GerontologyMalemedicine.medical_specialtyAgingNeurologyFrail ElderlyInflammationPre-frailtyBiochemistry03 medical and health sciencesFibrinogen levels0302 clinical medicineInternal medicineWhite blood cellmedicine80 and overHumans030212 general & internal medicineMolecular BiologyAgedAged 80 and overInflammationbiologyInflammation Pre-frailty Frailty Aging C-Reactive proteFrailtybusiness.industryInterleukin-6C-reactive proteinC-Reactive proteinInflammatory biomarkersAgeingmedicine.anatomical_structureAging; C-Reactive protein; Frailty; Inflammation; Interleukin-6; Pre-frailty; Aged; Aged 80 and over; Biomarkers; Cytokines; Female; Humans; Inflammation; Male; Frail ElderlyNeurologyMeta-analysisbiology.proteinCytokinesFemalemedicine.symptombusiness030217 neurology & neurosurgeryBiomarkersSystematic searchBiotechnologyAging; C-Reactive protein; Frailty; Inflammation; Interleukin-6; Pre-frailtydescription
The pathogenesis of frailty and the role of inflammation is poorly understood. We examined the evidence considering the relationship between inflammation and frailty through a systematic review and meta-analysis. A systematic literature search of papers providing data on inflammatory biomarkers and frailty was carried out in major electronic databases from inception until May 2016. From 1856 initial hits, 35 studies (32 cross-sectional studies n = 3232 frail, n = 11,483 pre-frail and n = 8522 robust, and 563 pre-frail + robust; 3 longitudinal studies n = 3402 participants without frailty at baseline) were meta-analyzed. Cross-sectional studies reported that compared to 6757 robust participants, both 1698 frail (SMD = 1.00, 95%CI: 0.40–1.61) and 8568 pre-frail (SMD = 0.33, 95%CI: 0.04–0.62) participants had significantly higher levels of C-reactive protein (CRP). Frailty (n = 1057; SMD = 1.12, 95%CI: 0.27–2.13) and pre-frailty (n = 4467; SMD = 0.56, 95%CI: 0.00–1.11) were associated with higher serum levels of interleukin-6 compared to people who were robust (n = 2392). Frailty and pre-frailty were also significantly associated with elevated white blood cell and fibrinogen levels. In three longitudinal studies, higher serum CRP (OR = 1.06, 95%CI: 0.78–1.44,) and IL-6 (OR = 1.19, 95%CI: 0.87–1.62) were not associated with frailty. In conclusion, frailty and pre-frailty are associated with higher inflammatory parameters and in particular CRP and IL-6. Further longitudinal studies are needed. © 2016 The Authors
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-11-01 |