Furostanol saponins and ecdysones with cytotoxic activity from Helleborus bocconei ssp. intermedius

6533b7defe1ef96bd1275e54

RESEARCH PRODUCT

Furostanol saponins and ecdysones with cytotoxic activity from Helleborus bocconei ssp. intermedius

Sergio Rosselli Vivienne Spadaro Carmen Formisano Antonella Maggio Carmen Maffettone Maurizio Bruno Carlo Irace Nicola Mascolo

subject

Ecdysone Stereochemistry Helleborus Saponin Ranunculaceae Pharmacognosy Cell Line furostanol saponin C6 glioma cell Animals Settore BIO/15 - Biologia Farmaceutica Medicinal plants Cytotoxicity cytotoxic activity Pharmacology chemistry.chemical_classification Molecular Structure Traditional medicine biology Plant Extracts Glycoside Biological activity Settore CHIM/06 - Chimica Organica Saponins biology.organism_classification Antineoplastic Agents Phytogenic Rats Helleborus Sterols chemistry H. bocconei subsp. intermediu Ranunculaceae

description

Two furostanol saponins helleboroside A (1) and helleboroside B (2) were isolated from the methanol extract of Helleborus bocconei Ten. subsp. intermedius (Guss.) Greuter and Burdet, along with the furospirostanol saponin 4 and two ecdysones: ecdysterone (5) and polypodyne B (6). Compound 2 was enzymatically hydrolysed to give product 3. The biological activity of all compounds was tested against rat C6 glioma cells showing a significant cytotoxicity for compounds 3, 4 and 6. Copyright © 2009 John Wiley & Sons, Ltd.

year	journal	country	edition	language
2009-01-01

10.1002/ptr.2569 http://hdl.handle.net/10447/38425

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