6533b7defe1ef96bd1275e60

RESEARCH PRODUCT

Synthesis of No-Carrier-Added 4-[18F]Fluorophenol from 4-Benzyloxyphenyl-(2-thienyl)iodonium Bromide

Heinz H. CoenenJohannes ErmertTobias L. Ross

subject

Fluorine Radioisotopespositron emission tomographyTwo stepNo carrier addedPharmaceutical ScienceThiophenesMedicinal chemistryAnalytical Chemistrylcsh:QD241-441chemistry.chemical_compoundOnium CompoundsPhenolsNucleophilelcsh:Organic chemistryBromideDrug DiscoveryMoietyOrganic chemistryPhysical and Theoretical Chemistrydiaryl iodonium saltsCommunicationOrganic ChemistrySynthonRadiosynthesischemistryChemistry (miscellaneous)fluorine-18Molecular MedicineradiosynthesisRadiopharmaceuticalsFluoride4-[18F]fluorophenol

description

4-[(18)F]Fluorophenol is a versatile synthon for the synthesis of more complex radiopharmaceuticals bearing a 4-[(18)F]fluorophenoxy moiety. In order to prepare 4-[(18)F]fluorophenol in no-carrier-added (n.c.a.) form only a nucleophilic labelling method starting from [(18)F]fluoride is suitable. In this paper a new, two step radiosynthesis starting from 4-benzyloxyphenyl-(2-thienyl)iodonium bromide and [(18)F]fluoride with subsequent deprotection is described, yielding n.c.a. [(18)F]fluorophenol in 34 to 36% radiochemical yield.

yearjournalcountryeditionlanguage
2011-08-11Molecules
10.3390/molecules16097621http://www.mdpi.com/1420-3049/16/9/7621/