6533b7defe1ef96bd1275e6a
RESEARCH PRODUCT
Arterial stiffness and ischemic stroke in subjects with and without metabolic syndrome.
Domenico Di RaimondoAntonio PintoRiccardo Di SciaccaGiuseppe LicataRosaria PecoraroAntonino TuttolomondoValentina ArnaoCarmelo Buttàsubject
Malemedicine.medical_specialtySettore MED/09 - Medicina InternaStroke arterial stiffness metabolic syndromePulse Wave AnalysisPathogenesisVascular StiffnessInternal medicineDiabetes mellitusmedicineHumanscardiovascular diseasesPulse wave velocityStrokeAgedAged 80 and overMetabolic Syndromebusiness.industryMiddle Agedmedicine.diseaseStrokeBlood pressureArterial stiffnessCardiologyFemaleMetabolic syndromeCardiology and Cardiovascular MedicinebusinessBody mass indexdescription
We conducted a study to evaluate arterial stiffness markers in subjects with acute ischemic stroke and metabolic syndrome and in relation to TOAST subtype of stroke. We enrolled 130 patients with acute ischemic stroke and metabolic syndrome, 127 patients with acute ischemic stroke without metabolic syndrome and 120 control subjects without acute stroke. Applanation tonometry to record pulse wave velocity (PWV). Stroke patients with metabolic syndrome, compared control subjects without stroke showed higher PWV. In subjects with ischemic stroke and metabolic syndrome, PWV was more significantly and positively correlated with body mass index, systolic blood pressure, hypertension, diabetes, glucose blood levels, LDL cholesterol levels, total cholesterol levels, micro-albuminuria, carotid plaque, previous brain infarct at neuro-imaging. Our findings underline important role of both small vessel disease and atherosclerosis on arterial stiffness pathogenesis in the clinical setting of metabolic syndrome.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-11-01 | Atherosclerosis |