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RESEARCH PRODUCT
Quercetin-Based Nanocomposites as a Tool to Improve Dental Disease Management
Viviana De CaroGiuseppina CampisiGiuseppe AngellottiDenise Murgiasubject
0301 basic medicinedental diseasemedicine.medical_treatmentMedicine (miscellaneous)DentistryReviewGeneral Biochemistry Genetics and Molecular BiologyOsseointegrationquercetin03 medical and health scienceschemistry.chemical_compoundHuman health0302 clinical medicineIn vivoantibacterial effectOral and maxillofacial pathologymedicineheterocyclic compoundsDental implantlcsh:QH301-705.5dental implantbusiness.industryRegeneration (biology)osteoinductive effectOsteoblast030206 dentistrymedicine.disease030104 developmental biologymedicine.anatomical_structurechemistrylcsh:Biology (General)businessQuercetinquercetin scaffolddescription
The restoration and prosthetic rehabilitation of missing teeth are commonly performed using dental implants, which are extremely effective and long-lasting techniques due to their osteointegration ability with the preimplant tissues. Quercetin is a phytoestrogen-like flavonoid well known for its several positive effects on human health, mostly linked to the anti-inflammatory, antioxidant, and antibacterial activities against both Gram-positive and Gram-negative bacteria. Moreover, many studies in dentistry and the maxillofacial fields have highlighted the positive effects of quercetin on osteogenesis, acting on osteoblast activity and angiogenetic process, and promoting soft and hard tissue regeneration. This review focuses on the role of quercetin on the healing and restoration of bony defects, considering the experimental findings of its application both in vitro and in vivo as a mere compound or in association with scaffolds and dental implants having functionalized surfaces.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-11-01 | Biomedicines |