Lipid multilayered particles: the role of chitosan on structure and morphology

6533b7defe1ef96bd1276353

RESEARCH PRODUCT

Lipid multilayered particles: the role of chitosan on structure and morphology

Yuri Gerelli Maria Teresa Di Bari Antonio Deriu Daniel Clemens László Almásy

subject

description

Multilayered nanovectors made up from a controlled binary lipid mixture (POPC and DMPS) and trimethyl chitosan (TMC) have been prepared and characterized by light- and small angle neutron scattering. The morphology and the multilayer structure of the particle outer shell has been described in detail. By varying the amount of TMC in the starting solution it is possible to tune the overall surface particle charge as well as its multilamellarity. In this way the drug loading/release properties of the particles can be controlled. Therefore the use of controlled POPC/DMPS mixtures can be a valid alternative to commercial lecithin to obtain nanovectors with specific release properties.

year	journal	country	edition	language
2010-11-02

http://doc.rero.ch/record/20885/files/Gerelli2010a.pdf

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