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RESEARCH PRODUCT

Concurrent Measurements of O2 Partial Pressures and pH Values in Human Mammary Carcinoma Xenotransplants

subject

description

Due to severe restrictions of convective and diffusive transport, hypoxic or even anoxic areas exist in malignant tumors. In addition, a high glycolytic rate in tumors both in the presence and absence of oxygen and the insufficient removal of the hereby produced lactic acid lead to an acidification of the tumor tissue. Both hypoxia and acidosis can influence the efficacy of irradiation, chemotherapy and hyperthermia. However, no comprehensive data on the development of both hypoxia and acidosis within the same tumor are available to date. In particular, there is no information regarding human tumors. Therefore, a new model has been developed which allows the systematic evaluation of both parameters in human tumor material in vivo under controlled systemic conditions. Due to its frequency and problematic clinical prognosis, cancer of the breast was chosen as the first tumor for investigation.