6533b7defe1ef96bd1276520

RESEARCH PRODUCT

Fate of Epdxides

Franz Oesch

subject

chemistry.chemical_classificationfungifood and beveragesCovalent bindingPolycyclic aromatic hydrocarbonCancerPrimary lesionmedicine.diseasechemistry.chemical_compoundEnzymechemistryBiochemistryStyrene oxidemedicineEpoxide hydrolaseDNA

description

One of the most important reactions of epoxides appears to be the covalent binding to DNA which can lead to mutagenicity and is strongly suspected to be the primary lesion ultimately leading to initiation of cancer (Miller and Miller, 1974; Oesch, 1973; Jerina and Daly, 1974; Sims and Grover, 1974; Heidelberger, 1975; Gelboin et al., 1972). This review first describes structure-activity relationships for the mutagenicity of some epoxides and then outlines some findings on the metabolic control of the concentration of such epoxides by a number of enzymes.

yearjournalcountryeditionlanguage
1982-01-01
https://doi.org/10.1007/978-1-4757-0674-1_3