6533b7defe1ef96bd12765da

RESEARCH PRODUCT

A DFT study of the asymmetric (S)-5-(pyrrolidin-2-yl)-1H-tetrazole catalyzed Michael addition of carbonyl compounds to nitroalkenes

Ramón J. ZaragozáLuis R. DomingoManuel Arnó

subject

ChemistryStereochemistryOrganic ChemistryNitroalkeneCatalysisCatalysisInorganic Chemistrychemistry.chemical_compoundIntramolecular forceMichael reactionMoietyReactivity (chemistry)TetrazoleStereoselectivityPhysical and Theoretical Chemistry

description

Abstract The role of the ( S )-5-(pyrrolidin-2-yl)-1 H -tetrazole in the asymmetric organocatalyzed Michael addition of carbonyl compounds to nitroalkenes has been studied using DFT methods at the B3LYP/6-31G ∗∗ computational level. For the C–C bond-formation step, several reactive channels have been analyzed. The B3LYP/6-31G ∗∗ results, which are in reasonable agreement with the experiments, allow us to explain the stereoselectivity and the increase of the reactivity achieved by an intramolecular HB between the acid hydrogen of the tetrazole moiety and one oxygen atom of the nitroalkene.

yearjournalcountryeditionlanguage
2007-02-01Tetrahedron: Asymmetry
https://doi.org/10.1016/j.tetasy.2007.01.011