6533b7defe1ef96bd1276773
RESEARCH PRODUCT
Electrical and mechanical activity of mammalian heart muscle fibres treated with papaverine
Thomas MeinertzHermann Nawrathsubject
Inotropemedicine.medical_specialtyReserpineGuinea PigsIn Vitro TechniquesMembrane PotentialsPapaverineIsoprenalineInternal medicinemedicineAnimalsDrug Interactionscardiovascular diseasesPharmacologyPapaverineCATSChemistryIsoproterenolHeartGeneral MedicinePapillary MusclesReserpineDibutyryl Cyclic AMPMyocardial ContractionMammalian heartEndocrinologyBucladesineCatscardiovascular systemAction potential durationmedicine.drugdescription
The action of papaverine on electrical and mechanical activity was investigated in ventricular and atrial heart muscle fibres from guinea-pigs and cats. 1. Papaverine (10−5 M–5×10−5M) had positive, negative or no inotropic effects in ventricular preparations; positive inotropic effects were not observed after pretreatment of the animals with reserpine. In atrial preparations, papaverine (2×10−5M) had a positive inotropic effect that was independent of endogenously stored catecholamines. 2. The effects of isoprenaline and dibutyryl cyclic AMP were potentiated by papaverine (10−5 M–2×10−5M). 3. The action potential duration was always prolonged by papaverine in ventricular as well as in atrial preparations. 4. In the presence of papaverine, ventricular preparations regularly developed spontaneous electrical and mechanical activity in response to moderate concentrations of isoprenaline or dibutyryl cyclic AMP.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1977-10-06 | Naunyn-Schmiedeberg's Archives of Pharmacology |