Cyclosporin- and nifedipine-induced gingival overgrowth in renal transplant patients: correlations with periodontal and pharmacological parameters, and HLA-antigens

6533b7defe1ef96bd1276794

RESEARCH PRODUCT

Cyclosporin- and nifedipine-induced gingival overgrowth in renal transplant patients: correlations with periodontal and pharmacological parameters, and HLA-antigens

Valerio Margiotta Ignazio Pizzo Adele Barbaro Giuseppe Pizzo

subject

Adult Male Cancer Research medicine.medical_specialty Adolescent Nifedipine Azathioprine Gastroenterology Pathology and Forensic Medicine Pathogenesis Nifedipine HLA Antigens Internal medicine Cyclosporin a Azathioprine Prevalence medicine Humans Periodontal Pocket Dental Calculus Child Saliva Kidney transplantation Kidney HLA-A Antigens Gingival Overgrowth business.industry Dental Plaque Index Middle Aged Calcium Channel Blockers medicine.disease Gingivitis Kidney Transplantation Transplantation Endocrinology medicine.anatomical_structure Otorhinolaryngology Toxicity Cyclosporine Irritants Periodontics Female Disease Susceptibility Periodontal Index Oral Surgery business Immunosuppressive Agents medicine.drug

description

The factors associated with cyclosporin A (CsA)- and nifedipine (Nif)-induced gingival overgrowth were investigated in 113 renal transplant recipients receiving CsA alone (Group 1) [n = 61], CsA and Nif (Group 2) [n = 28], or azathioprine (Aza) (Control Group) [n = 24]. Periodontal and pharmacological parameters were assessed for each patient. The patients with a gingival overgrowth index (GOI) score1 were considered responders (R); those with a score/= 1 were non-responders (NR). Gingival overgrowth occurred in 33.7% of the patients in Groups 1 and 2; 60% of the responders were receiving CsA+Nif. In R, no relationship was found between the GOI and the periodontal and pharmacological parameters, and although there was a trend towards an increased presence of HLA-A19 antigen (chi-square=4.40; P=0.04; RR=2.86), no significant difference was found between R and NR (Pc0.05). It is concluded that the prevalence and severity of gingival overgrowth are greater in patients receiving CsA+Nif. As overgrowth appeared to be unrelated to local irritants, gingival inflammation or pharmacological parameters, it may be related to individual susceptibility.

year	journal	country	edition	language
1996-03-01	Journal of Oral Pathology and Medicine

https://doi.org/10.1111/j.1600-0714.1996.tb00207.x