6533b7defe1ef96bd12767cf

RESEARCH PRODUCT

Pharmaceutical potential of synthetic and natural pyrrolomycins

Benedetta MaggioStella CascioferroDemetrio RaffaMaria Grazia CusimanoMaria Valeria RaimondiDomenico SchillaciGiuseppe Daidone

subject

Pyoluteorinantibiotic resistancemedicine.drug_classAntibioticsPharmaceutical ScienceMicrobial Sensitivity TestsReviewPharmacologyAntibiofilm agentpyrrolomycinSettore BIO/19 - Microbiologia GeneraleAnalytical Chemistrylcsh:QD241-441Antibiotic resistancelcsh:Organic chemistryDrug DiscoveryDrug Resistance BacterialMedicineAnimalsHumansPyrrolesClinical efficacyPhysical and Theoretical ChemistrypyrrolomycinspentabromopseudilinLow toxicityBacteriabusiness.industryOrganic ChemistryBiological activityBacterial Infectionsantibiofilm agentsAntimicrobialSettore CHIM/08 - Chimica FarmaceuticaAnti-Bacterial AgentsChemistry (miscellaneous)BiofilmsPentabromopseudilinMolecular MedicinebusinessAntibacterial activity

description

The emergence of antibiotic resistance is currently considered one of the most important global health problem. The continuous onset of multidrug-resistant Gram-positive and Gram-negative bacterial strains limits the clinical efficacy of most of the marketed antibiotics. Therefore, there is an urgent need for new antibiotics. Pyrrolomycins are a class of biologically active compounds that exhibit a broad spectrum of biological activities, including antibacterial, antifungal, anthelmintic, antiproliferative, insecticidal, and acaricidal activities. In this review we focus on the antibacterial activity and antibiofilm activity of pyrrolomycins against Gram-positive and Gram-negative pathogens. Their efficacy, combined in some cases with a low toxicity, confers to these molecules a great potential for the development of new antimicrobial agents to face the antibiotic crisis.

yearjournalcountryeditionlanguage
2015-12-04
10.3390/molecules201219797http://hdl.handle.net/10447/195177