6533b7defe1ef96bd127697d
RESEARCH PRODUCT
72/74As-labeling of HPMA based polymers for long-term in vivo PET imaging
Matthias BarzMatthias M. HerthMarkus JahnFrank RöschRudolf Zentelsubject
Time FactorsClinical BiochemistryPharmaceutical ScienceContext (language use)BiochemistryArsenicIn vivoDrug DiscoveryPolymer chemistrymedicineMolecular BiologyRadioisotopeschemistry.chemical_classificationAcrylamidesmedicine.diagnostic_testOrganic ChemistryArsenic isotopePositron emittersPolymerPet imagingchemistryPositron emission tomographyPositron-Emission TomographyBiophysicsMolecular MedicineMolecular imagingdescription
Abstract In the context of molecular imaging, various polymers based on the clinically approved N-(2-hydroxypropyl)-methacrylamide (HPMA) have been radio-labeled using longer-living positron emitters 72As t1/2 = 26 h or 74As t1/2 = 17.8 d. This approach may lead to non-invasive determination of the long-term in vivo fate of polymers by PET (positron emission tomography). Presumably, the radio label itself will not strongly influence the polymer structure due to the fact that the used nuclide binds to already existing thiol moieties within the polymer structure. Thus, the use of additional charges or bulky groups can be avoided.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-05-29 | Bioorganic & Medicinal Chemistry Letters |