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RESEARCH PRODUCT

Synthesis and antifungal activity of new N-isoxazolyl-2-iodobenzamides

Benedetta MaggioGiuseppe DaidoneFabiana PlesciaLivio TortaDemetrio RaffaDomenico Schillaci

subject

Phytophthora citricolaMagnetic Resonance SpectroscopyChemical PhenomenaSpectrophotometry Infraredmedicine.drug_classStereochemistryColony Count MicrobialPharmaceutical ScienceCarboxamideRhizoctoniaChemical synthesisAcetic acidchemistry.chemical_compoundN-Isoxazolyl-2-iodobenzamideDrug DiscoverymedicineAntifungal activityBotrytis cinereabiologyChemistry PhysicalfungiFungifood and beveragesIsoxazolesbiology.organism_classificationAlternariaSettore CHIM/08 - Chimica FarmaceuticaFungicides IndustrialFungicidechemistryBenzamides

description

N-Isoxazolyl-2-iodobenzamides 3 and 9, with a benodanil-like structure, were synthesized by refluxing in acetic acid the corresponding benzotriazinones 2 and 8 with potassium iodide for 1 h with the aim to ascertain if they were active as fungicides against Phytophthora citricola Saw., Botrytis cinerea Pers., Rhizoctonia sp. and Alternaria sp. Among the tested iodo derivatives, compounds 3b and 9a possess interesting activities against the aforesaid fungal strains in several cases similar to that of benodanil I taken as reference drug.

yearjournalcountryeditionlanguage
1999-05-13
10.1016/s0014-827x(98)00108-6http://hdl.handle.net/10447/146161