6533b81ffe1ef96bd1276fe5
RESEARCH PRODUCT
Catalytic Asymmetric Reactions Involving the Seven-Membered Cyclic Imine Moieties Present in Dibenzo[b,f][1,4]oxazepines
Carlos VilaLode De MunckJosé R. Pedrosubject
010405 organic chemistryStereochemistryOrganic ChemistryImineEnantioselective synthesisSubstrate (chemistry)010402 general chemistry01 natural sciences0104 chemical sciencesCatalysischemistry.chemical_compoundchemistryElectrophileOxazepinePhysical and Theoretical ChemistryDibenzoxazepinesdescription
The dibenzo[b,f][1,4]oxazepine scaffold is a privileged structure in medicinal chemistry that displays a wide variety of biological and pharmacological activities. However, catalytic asymmetric methodologies for the synthesis of chiral dibenzo[b,f][1,4]oxazepine derivatives are scarce in the literature. This microreview presents an overview of enantioselective reactions in which these cyclic seven-membered imines are used as electrophiles, including their substrate scope, limitations and application to the synthesis of related compounds.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-11-20 | European Journal of Organic Chemistry |