6533b81ffe1ef96bd127711b

RESEARCH PRODUCT

Airways Hyperresponsiveness and the Effects of Lung Inflation

Christina AnderlindGeorge PyrgosRobert H. BrownSolbert PermuttTrigsevgeni KapsaliNicola ScichiloneAlkis Togias

subject

Allergymedicine.drug_classImmunologyProvocation testSettore MED/10 - Malattie Dell'Apparato RespiratorioNitric OxideModels BiologicalBronchial Provocation TestsBronchoconstrictor AgentsForced Expiratory VolumeBronchodilatormedicineHumansImmunology and AllergyMethacholine ChlorideAsthmabusiness.industryRespiratory diseaseGeneral Medicinerespiratory systemmedicine.diseaseAsthmarespiratory tract diseasesBronchial Provocation Testmedicine.anatomical_structureBronchoconstrictor AgentImmunologyBronchoconstrictionMethacholineBronchial Hyperreactivitymedicine.symptomPulmonary VentilationbusinessHumanRespiratory tractmedicine.drug

description

Lung inflation has a beneficial effect on the airways of healthy subjects. It acts as a bronchoprotector, that is to prevent bronchoconstriction, and as a bronchodilator, in that it reverses bronchial obstruction. The bronchoprotective effect of deep inspiration is more potent than the bronchodilatory one, and the two phenomena appear to advocte different mechanisms. Asthmatics and rhinitics with airways hyperresponsiveness show an impairment in bronchoprotection induced by deep breaths, whereas the bronchodilatory effect, although reduced, is still effective. The lack of the bronchoprotective effect of deep inspiration may contribute to the development of airways hyperresponsiveness. The mechanisms through which lung inflation exerts its beneficial role in healthy subjects, and the factors impairing such an effect in those with airways hyperresponsiveness, are currently under investigation.

yearjournalcountryeditionlanguage
2001-04-18International Archives of Allergy and Immunology
https://doi.org/10.1159/000053728