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RESEARCH PRODUCT
Linoleic acid: Is this the key that unlocks the quantum brain? Insights linking broken symmetries in molecular biology, mood disorders and personalistic emergentism
Lucio TonelloMark M. RasenickJack A. TuszynskiChiara MinutoGustav BernroiderMassimo CocchiFrancesco CappelloFabio Gabriellisubject
0301 basic medicinePhase transitionLinoleic acidMood DisorderModels NeurologicalPhysical systemAntidepressantContext (language use)MicrotubuleReviewlcsh:RC321-57103 medical and health sciencesCellular and Molecular Neuroscience0302 clinical medicineAntidepressants; Cytoskeleton; Depression; Ion channels; Ising model; Linoleic acid; Lipid raft; Microtubule; Mood disorders; Quantum states; Linoleic Acid; Mood Disorders; Brain; Models Neurological; Neuroscience (all); Cellular and Molecular NeuroscienceIsing modelCytoskeletonlcsh:Neurosciences. Biological psychiatry. NeuropsychiatryLipid raftQuantumIon channelCytoskeletonNeuroscience (all)ChemistryDepressionGeneral Neurosciencelcsh:QP351-495BrainQuantum statesMood disorders Linoleic acid Ion channels Cytoskeleton Microtubule Lipid raft Depression Antidepressants Ising model Quantum statesAntidepressantsQuantum stateLipid raftlcsh:Neurophysiology and neuropsychology030104 developmental biologyIon channelsMood disordersIsing modelIon channelNeuroscience030217 neurology & neurosurgerydescription
Abstract In this paper we present a mechanistic model that integrates subneuronal structures, namely ion channels, membrane fatty acids, lipid rafts, G proteins and the cytoskeleton in a dynamic system that is finely tuned in a healthy brain. We also argue that subtle changes in the composition of the membrane’s fatty acids may lead to down-stream effects causing dysregulation of the membrane, cytoskeleton and their interface. Such exquisite sensitivity to minor changes is known to occur in physical systems undergoing phase transitions, the simplest and most studied of them is the so-called Ising model, which exhibits a phase transition at a finite temperature between an ordered and disordered state in 2- or 3-dimensional space. We propose this model in the context of neuronal dynamics and further hypothesize that it may involve quantum degrees of freedom dependent upon variation in membrane domains associated with ion channels or microtubules. Finally, we provide a link between these physical characteristics of the dynamical mechanism to psychiatric disorders such as major depression and antidepressant action.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-04-01 |