6533b81ffe1ef96bd1277268
RESEARCH PRODUCT
Reduction of red-green discrimination by dopamine D1 receptor antagonists and retinal dopamine depletion
Christa NeumeyerCarlos Mora-ferrersubject
DopamineWavelength discriminationRetinaHydroxydopamineschemistry.chemical_compoundDiscrimination PsychologicalDopamine receptor D1OpticsDopamineGoldfishmedicineAnimalsNeurotoxinDopamine receptorsNeurotransmitterRetinabusiness.industryReceptors Dopamine D1DopaminergicRetinalSensory SystemsOphthalmologymedicine.anatomical_structurechemistryDopamine receptorDopamine AgonistsBiophysicssense organsbusinessColor Perceptionmedicine.drugdescription
AbstractReduction of wavelength discrimination ability in the 560–640 nm range, but not in the 404–540 nm range, has been demonstrated in goldfish after intravitreal injection of D1-dopamine receptor antagonists. Intravitreal injection of the dopaminergic neurotoxin 6-OH-dopamine severely reduced wavelength discrimination ability in the 540–661 nm range within 3 days. Discrimination ability could be reconstituted by the Dl-agonist SKF 38393. Animals recovered from injection of 6-OH-dopamine within 14–16 days. No change of wavelength discrimination was induced by 6-OH-dopamine in the 461–540 nm range. We conclude that under photopic conditions dopamine modulates retinal mechanisms involved in red-green colour coding via D1-dopamine receptor-like binding sites.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1996-12-01 | Vision Research |