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RESEARCH PRODUCT
Serum and urine 1H NMR-based metabolomics in the diagnosis of selected thyroid diseases
Piotr MłynarzAdam ZabekMateusz GłódTomasz DawiskibaWojciech WojtowiczDorota PawełkaWaldemar BalcerzakStanislaw Dejasubject
0301 basic medicinePathologymedicine.medical_specialtyMultidisciplinarybusiness.industryScienceThyroidQCase-control studyREarly detectionUrinemedicine.disease03 medical and health sciences030104 developmental biology0302 clinical medicineMetabolomicsmedicine.anatomical_structureBlood serum030220 oncology & carcinogenesisAspiration biopsymedicineMedicinebusinessThyroid cancerdescription
AbstractEarly detection of nodular thyroid diseases including thyroid cancer is still primarily based on invasive procedures such as fine-needle aspiration biopsy. Therefore, there is a strong need for development of new diagnostic methods that could provide clinically useful information regarding thyroid nodular lesions in a non-invasive way. In this study we investigated 1H NMR based metabolic profiles of paired urine and blood serum samples, that were obtained from healthy individuals and patients with nodular thyroid diseases. Estimation of predictive potential of metabolites was evaluated using chemometric methods and revealed that both urine and serum carry information sufficient to distinguish between patients with nodular lesions and healthy individuals. Data fusion allowed to further improve prediction quality of the models. However, stratification of tumor types and their differentiation in relation to each other was not possible.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-08-01 | Scientific Reports |