A comparative analysis of the products of GROEL-1 gene fromChlamydia trachomatisserovar D and the HSP60 var1 transcript fromHomo sapienssuggests a possible autoimmune response

6533b81ffe1ef96bd1277277

RESEARCH PRODUCT

A comparative analysis of the products of GROEL-1 gene fromChlamydia trachomatisserovar D and the HSP60 var1 transcript fromHomo sapienssuggests a possible autoimmune response

Claudia Campanella A. Marino Gammazza L. Mularoni V. Di Felice Francesco Cappello Giovanni Zummo

subject

Serotype animal structures Transcription Genetic Molecular Sequence Data Immunology Autoimmunity Chlamydia trachomatis chemical and pharmacologic phenomena Biology medicine.disease_cause complex mixtures Epitope Autoimmunity Genetics medicine Humans Amino Acid Sequence Molecular Biology Gene Genetics (clinical)Genetics Base Sequence fungi Chaperonin 60 General Medicine Chlamydia Infections Hsp60 Chlamydia trachomatis GroEL Homo sapiens HSP60 Chlamydia trachomatis Sequence Alignment

description

Summary Chlamydia trachomatis serovar D produces large quantities of HSP60-1 during infections, which accumulate inside the host cell inducing autoimmunity. We compare the aminoacid sequences of the human HSP60 with the bacterial counterpart to better elucidate how CTHSP60 may simulate HSP60 from human origin during infection and may induce an autoimmune response. As a result of the comparison we suggest several possible epitopes of the CTHSP60, which may induce autoimmunity.

year	journal	country	edition	language
2009-02-12	International Journal of Immunogenetics

https://doi.org/10.1111/j.1744-313x.2008.00819.x

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