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RESEARCH PRODUCT
Cytotoxic geranylflavonoids from Bonannia graeca
Sergio RosselliKenneth F. BastowRosa Angela RaccugliaMuhammad SafderKuo Hsiung LeeChin Yu LaiAntonella MaggioMaurizio Brunosubject
Synthetic derivativesStereochemistryChemical structurePlant ScienceHorticultureBiochemistryArticleStructure-Activity RelationshipBonannia graecaCell Line TumorHumansCytotoxic T cellStructure–activity relationshipSettore BIO/15 - Biologia FarmaceuticaGeranylflavonoidsMolecular BiologyFlavonoidsApiaceaeMolecular StructurebiologyCytotoxic activityfungiEuphorbiaceaefood and beveragesGeneral MedicineSettore CHIM/06 - Chimica OrganicaPlant Components Aerialbiology.organism_classificationAntineoplastic Agents PhytogenicHuman tumorTwo-dimensional nuclear magnetic resonance spectroscopyApiaceaedescription
The analysis of the aerial parts of Bonannia graeca led to the isolation and characterization of two new polar geranylated flavonoids (6 and 7). The structure elucidation was performed by extensive spectroscopic methods (1D and 2D NMR) and comparison with literature data. All natural flavonoids isolated from B. graeca (1–7) and some synthetic derivatives (8–11) were tested for cytotoxic activity against four human tumor cell lines. Preliminary structure-activity relationship correlations are discussed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2011-01-01 |