0000000000437233

AUTHOR

Muhammad Safder

0000-0003-3698-2758

showing 4 related works from this author

Cytotoxic geranylflavonoids from Bonannia graeca

2011

The analysis of the aerial parts of Bonannia graeca led to the isolation and characterization of two new polar geranylated flavonoids (6 and 7). The structure elucidation was performed by extensive spectroscopic methods (1D and 2D NMR) and comparison with literature data. All natural flavonoids isolated from B. graeca (1–7) and some synthetic derivatives (8–11) were tested for cytotoxic activity against four human tumor cell lines. Preliminary structure-activity relationship correlations are discussed.

Synthetic derivativesStereochemistryChemical structurePlant ScienceHorticultureBiochemistryArticleStructure-Activity RelationshipBonannia graecaCell Line TumorHumansCytotoxic T cellStructure–activity relationshipSettore BIO/15 - Biologia FarmaceuticaGeranylflavonoidsMolecular BiologyFlavonoidsApiaceaeMolecular StructurebiologyCytotoxic activityfungiEuphorbiaceaefood and beveragesGeneral MedicineSettore CHIM/06 - Chimica OrganicaPlant Components Aerialbiology.organism_classificationAntineoplastic Agents PhytogenicHuman tumorTwo-dimensional nuclear magnetic resonance spectroscopyApiaceae
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Artalbic acid, a sesquiterpene with an unusual skeleton from Artemisia alba (Asteraceae) from Sicily

2011

Abstract From the aerial parts of Artemisia alba (Asteraceae) artalbic acid ( 1 ), a sesquiterpene with an unusual skeleton, was isolated. Its structure was elucidated on the basis of extensive proton, 13 C and two-dimensional NMR experiments, as well as by transformation in its methyl ester derivative.

biologyStereochemistryOrganic ChemistrySettore CHIM/06 - Chimica OrganicaAsteraceaeSesquiterpenebiology.organism_classificationBiochemistrySkeleton (computer programming)chemistry.chemical_compoundchemistryDrug DiscoveryArtemisiaSesquiterpene Irregular skeleton Asteraceae Artemisia albaTetrahedron Letters
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The metabolites of the genus onopordum (asteraceae): Chemistry and biological properties

2011

Onopordum is an interesting genus belonging to the tribe Cardueae (Asteraceae family), and the species of this genus are used as food and in the popular medicine of several countries. The present paper reviews all the metabolites present in all the species of this genus, reported up to 2009, and several chemotaxonomic consideration have been made. Furthermore, the occurrence in other genus, the spectral data, the synthetic approaches, the chemical modifications and the biological properties of the sesquiterpenes of genus Onopor- dum have been reviewed.

13C NMRbiologyOnopordumBiological activitySesquiterpenoidOrganic ChemistryZoologySettore CHIM/06 - Chimica OrganicaAsteraceaebiology.organism_classificationTribe (biology)Steroids and triterrpeneSynthesisGenusBiological propertyBotanyFlavonoidChemcial modificationSpectral data
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ChemInform Abstract: Artalbic Acid, a Sesquiterpene with an Unusual Skeleton from Artemisia alba (Asteraceae) from Sicily.

2011

Abstract From the aerial parts of Artemisia alba (Asteraceae) artalbic acid ( 1 ), a sesquiterpene with an unusual skeleton, was isolated. Its structure was elucidated on the basis of extensive proton, 13 C and two-dimensional NMR experiments, as well as by transformation in its methyl ester derivative.

Terpenechemistry.chemical_compoundchemistrybiologyStereochemistryArtemisiaGeneral MedicineAsteraceaeSesquiterpenebiology.organism_classificationSkeleton (computer programming)ChemInform
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