6533b81ffe1ef96bd1277339

RESEARCH PRODUCT

Multifunctional Poly(ethylene glycol)s

Boris ObermeierFrederik R. WurmChristine MangoldHolger Frey

subject

LymphomapolyethersNanotechnologyAntineoplastic AgentsPolyethylene glycolMolecular-WeightCatalysisPolyethylene Glycolschemistry.chemical_compoundepoxidesCopolymerOrganic chemistryAnimalsLiving anionic polymerizationchemistry.chemical_classificationWeight Hyperbranched PolyglycerolsDrug CarriersDrug-Delivery SystemsEthylene oxidepoly(ethylene glycol)Ethylene-OxideGene Transfer TechniquesPolymer TherapeuticsGeneral ChemistryPolymermultivalencybioconjugatesPendant Amino-GroupsPolyethylene-GlycolchemistryPolymerizationAnionic Peg DerivativesDoxorubicinBlock-CopolymersCisplatinIn-VivoDrug carrierPeptidesEthylene glycol

description

In the rapidly evolving multidisciplinary field of polymer therapeutics, tailored polymer structures represent the key constituent to explore and harvest the potential of bioactive macromolecular hybrid structures. In light of the recent developments for anticancer drug conjugates, multifunctional polymers are becoming ever more relevant as drug carriers. However, the potentially best suited polymer, poly(ethylene glycol) (PEG), is unfavorable owing to its limited functionality. Therefore, multifunctional linear copolymers (mf-PEGs) based on ethylene oxide (EO) and appropriate epoxide comonomers are attracting increased attention. Precisely engineered via living anionic polymerization and defined with state-of-the-art characterization techniques-for example real-time (1)H NMR spectroscopy monitoring of the EO polymerization kinetics-this emerging class of polymers embodies a powerful platform for bio- and drug conjugation.

yearjournalcountryeditionlanguage
2011-07-12
https://infoscience.epfl.ch/record/171054