6533b81ffe1ef96bd12779ba

RESEARCH PRODUCT

Increase in Endogenous Fibrinolysis and Platelet Activity during Exercise in Young Volunteers

Treese NBeisiegel BHafner GHarald DariusJuergen Meyer

subject

medicine.medical_specialtybusiness.industrymedicine.drug_classmedicine.medical_treatmentmedicine.diseaseTissue plasminogen activatorThrombosisEndocrinologyClinical researchEstrogenInternal medicineFibrinolysismedicinePlatelet activationbusinessPlasminogen activatorAnaerobic exercisemedicine.drug

description

Physicians at the Medical Clinic at the Johannes Gutenberg University in Mainz Germany compared data on 6 18-35 year old healthy women who took low-dose estrogen oral contraceptives (OCs) with data on 10 healthy women of same age who did not take OCs and with data on 12 18-35 year old males to examine gender differences of the coagulation system endogenous fibrinolytic activity and platelet aggregation under normal conditions and immediately after spiroergometric exercise beyond the anaerobic threshold. This type of exercise considerably boosted tissue plasminogen activator (t-PA) in both men and women (1.6-5.5 IU/ml and 1.8-5.3 IU/ml respectively; p < .005). The increase was not as high in women using the low-dose estrogen OCs as it was for men and both groups combined however; but the increase was still significant (1.5-3.8 IU/ml; p < .005). Plasma lactate levels were 1.1 mmol/l in men and 0.5 mmol/l in both female groups and rose significantly in all 3 groups (about 5.5 mmol/l for men and about 2.5 mmol/l for women; p < .001). Exercise beyond the anaerobic threshold did not change plasminogen activator inhibitor-I activities. A marked fall in the ED50 values for adenosine diphosphate (ADP) in men indicated considerable enhancement of platelet activity during exercise (p < .05). ADP ED50 values did not change significantly in either womens groups. Yet women who took the OCs had a lower ED50 for ADP than both men and women not taking the OCs suggesting they were more susceptible to platelet aggregation under control conditions and after exercise. These findings indicated a considerable gender difference in platelet aggregation and activation of the endogenous fibrinolytic system both at rest and during exercise. It was also pointed out that women taking OCs are at even greater risk of developing thrombosis than women not taking OCs.

https://doi.org/10.1007/978-3-0348-7262-1_25