6533b81ffe1ef96bd1277aad
RESEARCH PRODUCT
Low-Dose Aclacinomycin and Intermediate-Dose Cytosine Arabinoside in Relapsed and Refractory Acute Myelogenous Leukemia
François HerrmannK. HöffkenG. KüstersAlbrecht LindemannH. G. FuhrFelicia Dr RosenthalKarin KolbeR H Mertelsmannsubject
medicine.medical_specialtyMitoxantroneDaunorubicinbusiness.industryLow dosemedicine.diseaseGastroenterologyMyelogenouschemistry.chemical_compoundLeukemiaRefractorychemistryInternal medicinemedicinePrimary treatmentbusinessCytosinemedicine.drugdescription
Nineteen patients with relapsed or refractory acute myelogenous leukemia were treated with escalating doses of aclacinomycin (ACLA 20–30 mg/m2 daily for 5 days) and intermediate-dose cytosine arabinoside (Ara-C 1 g/m2 twice daily for 4 days). Most patients had received previous therapy with high- or intermediate-dose Ara-C plus mitoxantrone (HAM, IAM) and TAD (6-thioguanine, standard-dose cytosine arabinoside, and daunorubicin). Four patients had had repeated relapses and another three were treated for primary treatment failure following induction with HAM or I AM.
year | journal | country | edition | language |
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1990-01-01 |