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RESEARCH PRODUCT

Résistance aux antifongiques azolés d’origine environnementale : quelles alternatives pour l’avenir ?

Laurence MillonGabriel RebouxSteffi Rocchi

subject

chemistry.chemical_classificationFungicideFungal proteinInfectious DiseaseschemistryResistant strainAzoleBiologyAzole antifungalbiology.organism_classificationMicrobiologyAspergillus fumigatus

description

Azole resistant Aspergillus fumigatus strains are increasingly reported in many countries. One resistance mechanism is attributed to the use of azole fungicides in environment. Two mutations, TR34/L98H and TR46/Y121F/T289A, on the cyp51A gene, have been described. Results of 40 publications about azole resistant strain detections, with TR34/L98H and TR46/Y121F/T289A mutations, in clinical and/or environmental samples, are presented in this review. These cases, observed in many countries, suggest spreading phenomenon. Measures to moderate fungicides treatments and/or alternative treatments in environment should be established to preserve the effectiveness of azole antifungal therapy for at-risk patients.

yearjournalcountryeditionlanguage
2015-12-01Journal de Mycologie Médicale
https://doi.org/10.1016/j.mycmed.2015.10.008