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RESEARCH PRODUCT

TLR2 modulates gut colonization and dissemination of Candida albicans in a murine model

M. Luisa GilVictoria ManeuDaniel PrietoNuria CarpenaJesús PlaDaniel Gozalbo

subject

0301 basic medicinemedicine.drug_classFarmacología030106 microbiologyImmunologyAntibioticsEndogenyGut colonizationMicrobiologyMicrobiology03 medical and health sciencesImmunosuppressed miceCandida albicansmedicineTLR2AnimalsCandidiasis InvasiveColonizationCandida albicansMice KnockoutGastrointestinal tractbiologyWild typebiology.organism_classificationToll-Like Receptor 2Corpus albicansGastrointestinal TractMice Inbred C57BLTLR2030104 developmental biologyInfectious DiseasesImmunologyDisease Susceptibility

description

Invasive candidiasis often arises from translocation of endogenous yeasts from the gastrointestinal tract to the bloodstream. Here we describe that both wild type and TLR2−/− mice strains, orally administered with Candida albicans yeasts, display similar sustained high level of gut colonization when oral antibacterial treatment is present, while removal of antibiotic treatment causes a progressive clearance of yeasts in control but not in TLR2−/− mice. Fungal invasion of internal organs, following immunosuppression of colonized mice, was increased in TLR2−/− mice. These results point out to a role of TLR2 in gut protection against colonization and endogenous invasion by C. albicans. This work was supported by grant PI080556 (Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación, Spain) and BIO2012-31839 (Ministerio de Ciencia e Innovación, Spain).

yearjournalcountryeditionlanguage
2016-10-01Microbes and Infection
https://doi.org/10.1016/j.micinf.2016.05.005