6533b81ffe1ef96bd1277b3a
RESEARCH PRODUCT
Hyaluronic acid and beta cyclodextrins films for the release of corneal epithelial cells and dexamethasone
Gaetano GiammonaFlavia BongiovìCalogero FioricaFabio Salvatore PalumboGiovanna Pitarresisubject
Materials Chemistry2506 Metals and AlloysPolymers and Plasticsmedicine.medical_treatmentCellBeta-CyclodextrinsCell release systemmacromolecular substances02 engineering and technologyPharmacology010402 general chemistry01 natural sciencesDexamethasoneSteroidCorneachemistry.chemical_compoundCorneaHyaluronic acidMaterials ChemistrymedicineCorneal woundHumansHyaluronic acid hydrogelHyaluronic AcidDexamethasoneCells CulturedDrug CarriersPolymers and Plasticbeta-CyclodextrinsOrganic Chemistrytechnology industry and agricultureEpithelial CellsHydrogelsAnatomy021001 nanoscience & nanotechnologyeye diseases0104 chemical sciencesTransplantationDrug Liberationmedicine.anatomical_structurechemistrySettore CHIM/09 - Farmaceutico Tecnologico ApplicativoSelf-healing hydrogelssense organs0210 nano-technologymedicine.drugdescription
In this work we prepared hydrogels based on hyaluronic acid and β-cyclodextrins to sustain the release of both corneal epithelial cells and dexamethasone. This steroid is administered as eye drops several times per day to reduce the risk of rejection in the post operative period after the cornea transplantation and cell release techniques. Hydrogels were produced by crosslinking an amino derivative of hyaluronic acid, with the divinyl sulfone derivative of β-cyclodextrins, this last employed as a crosslinker and solubilizing agent. Drug release studies revealed that dexamethasone containing samples are able to extend the release of this drug for at least five days. Biological studies, conducted with human corneal epithelial cells, showed that it is possible to employ the hydrogels for the temporary seeding of the cells and their potential release onto the cornea.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-11-11 |