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RESEARCH PRODUCT

Liver Steatosis and Fibrosis in OSA patients After Long-term CPAP Treatment: A Preliminary Ultrasound Study.

Roberto VirdoneM. OlivoAlessandra CastrogiovanniMaria R. BonsignoreMaria R. BonsignoreEmilia MazzucaAnna Maria MarottaOreste MarroneMaria ButtacavoliSalvatore MadoniaClaudia I. Gruttad'auria

subject

Liver CirrhosisMalemedicine.medical_specialtyAcoustics and Ultrasonicsmedicine.medical_treatmentBiophysicsSettore MED/10 - Malattie Dell'Apparato RespiratorioGastroenterologyBody Mass IndexTime03 medical and health sciences0302 clinical medicineFibrosisInternal medicinemedicineHumansRadiology Nuclear Medicine and imagingObesityContinuous positive airway pressureNon-invasive assessmentUltrasonographySleep Apnea ObstructiveRadiological and Ultrasound Technologymedicine.diagnostic_testContinuous Positive Airway Pressurebusiness.industryFatty liverLiver fibrosiMiddle Agedmedicine.diseaseObstructive sleep apneanervous system diseasesrespiratory tract diseasesSurgeryObstructive sleep apneaFatty Liver030228 respiratory systemApnea–hypopnea indexLiverLiver steatosiFeasibility Studies030211 gastroenterology & hepatologyFemaleElastographyLongitudinal studySteatosisbusinessBody mass index

description

In cases of morbid obesity, obstructive sleep apnea (OSA) was associated with biopsy-proven liver damage. The role of non-invasive techniques to monitor liver changes during OSA treatment with continuous positive airway pressure (CPAP) is unknown. We used non-invasive ultrasound techniques to assess liver steatosis and fibrosis in severe OSA patients at diagnosis and during long-term CPAP treatment. Fifteen consecutive patients with severe OSA (apnea hypopnea index 52.5 ± 19.1/h) were studied by liver ultrasound and elastography (Fibroscan) at 6-mo (n = 3) or 1-y (n = 12) follow-up. Mean age was 49.3 ± 11.9 y, body mass index (BMI) was 35.4 ± 6.4 kg/m(2). Adherence to CPAP was ≥5 h/night. At baseline, most patients had severe liver steatosis independent of BMI; at follow-up, liver steatosis was not statistically different, but a relationship between severity of steatosis and BMI became apparent (Spearman's rho: 0.53, p = 0.03). Significant fibrosis as assessed by Fibroscan was absent at diagnosis or follow-up (failure or unreliable measurements in four markedly obese patients). Therefore, ultrasound liver assessment is feasible in most OSA patients, and CPAP treatment may positively affect liver steatosis.

yearjournalcountryeditionlanguage
2015-02-26Ultrasound in medicinebiology
10.1016/j.ultrasmedbio.2015.08.009https://pubmed.ncbi.nlm.nih.gov/26385053