6533b81ffe1ef96bd1277c0c

RESEARCH PRODUCT

Kinetics of echinostoma caproni (trematoda: echinostomatidae) antigens in feces and serum of experimentally infected hamsters and rats

Rafael ToledoJ. Guillermo EstebanCarla Muñoz-antoliAna EspertBernard FriedBernard FriedAntonio Marcilla

subject

MaleTime FactorsAntibodies HelminthHamsterEchinostoma caproniEnzyme-Linked Immunosorbent Assay:CIENCIAS DE LA VIDA [UNESCO]MicrobiologyEchinostomatidaeFecesAntigenCricetinaeEchinostomaUNESCO::CIENCIAS DE LA VIDAAnimalsParasite hostingAntigensRats WistarEcology Evolution Behavior and SystematicsFecesEchinostomiasisMesocricetusbiology:CIENCIAS DE LA VIDA::Biología animal (Zoología) ::Parasitología animal [UNESCO]Tissue migrationbiology.organism_classificationRatsEchinostoma caproni ; Antigens ; Hamsters ; RatsKineticsUNESCO::CIENCIAS DE LA VIDA::Biología animal (Zoología) ::Parasitología animalAntigens HelminthImmunologyHamstersParasitologyTrematodaEchinostoma

description

This study reports on the kinetics of antibody production to Echinostoma caproni and the dynamics of antigens in feces and sera in 2 experimental hosts (hamsters and rats) that display different degrees of susceptibility with this echinostome. Echinostoma caproniproduced chronic infections in hamsters, whereas rats lost the infection at 49-56 days postinfection (DPI). Hamsters developed higher antibody responses than rats, probably in relation to different intestinal absorptions of worm antigens in each host species. The levels of coproantigens were indicative of the course of infection in each host. Positive coproantigen levels were detected at 1-2 DPI in both hosts, and the values remained positive until the end of the experiment in hamsters; in rats, the coproantigen levels reverted to negative values, coinciding with the loss of infection. High levels of circulating antigens were detected in hamsters from 21 DPI to the end of the study. In contrast, low levels of E. caproni seroantigens were detected in rats only. These observations may reflect the differences in local inflammatory responses induced by E. caproni in each host species. Infections with intestinal trematodes are widespread. Despite the frequency of these infections, the relationships between in- testinal trematodes and their final hosts have received little at- tention. Echinostoma caproni(Trematoda: Echinostomatidae) is an intestinal trematode that does not undergo tissue migration in its definitive host. After infection of the definitive host with E. caproni, the metacercariae excyst in the duodenum, and the juvenile parasites migrate to the posterior third of the small

yearjournalcountryeditionlanguage
2004-01-01
10.1645/ge-279rhttp://hdl.handle.net/10550/16776